11th Report on Carcinogens

U.S. Department of Health and Human Services
Public Health Service
National Toxicology Program
Pursuant to Section 301(b) (4) of the Public Health Service Act as Amended by Section 262, PL 95-622

Official Citation: Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program .


Table of Contents

I. Introduction

II. Carcinogens Listed in the Eleventh Report

A. Known to be Human Carcinogens
B. Reasonably Anticipated to be Human Carcinogens

III. Substance Profiles

Acetaldehyde
2-Acetylaminofluorene
Acrylamide
Acrylonitrile
Adriamycin® (Doxorubicin Hydrochloride)
Aflatoxins
Alcoholic Beverage Consumption
2-Aminoanthraquinone
o-Aminoazotoluene
4-Aminobiphenyl
1-Amino-2,4-dibromoanthraquinone
1-Amino-2-methylanthraquinone
Amitrole
o-Anisidine Hydrochloride
Arsenic Compounds, Inorganic
Asbestos
Azacitidine
Azathioprine
Benzene
Benzidine and Dyes Metabolized to Benzidine
          Benzidine
          Dyes Metabolized to Benzidine
Benzotrichloride
Beryllium and Beryllium Compounds
Bromodichloromethane
2,2-bis(Bromomethyl)-1,3-propanediol (Technical Grade)
1,3-Butadiene
1,4-Butanediol Dimethylsulfonate (Myleran®)
Butylated Hydroxyanisole (BHA)
Cadmium and Cadmium Compounds
Carbon Tetrachloride
Ceramic Fibers (Respirable Size)
Chlorambucil
Chloramphenicol
Chlorendic Acid
Chlorinated Paraffins (C12, 60% Chlorine)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
bis(Chloroethyl) Nitrosourea
Chloroform
bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether
3-Chloro-2-methylpropene
4-Chloro-o-phenylenediamine
Chloroprene
p-Chloro-o-toluidine and p-Chloro-o-toluidine Hydrochloride
Chlorozotocin
Chromium Hexavalent Compounds
C.I. Basic Red 9 Monohydrochloride
Cisplatin
Coal Tars and Coal Tar Pitches
Cobalt Sulfate
Coke Oven Emissions
p-Cresidine
Cupferron
Cyclophosphamide
Cyclosporin A
Dacarbazine
Danthron (1,8-Dihydroxyanthraquinone)
2,4-Diaminoanisole Sulfate
2,4-Diaminotoluene
Diazoaminobenzene
1,2-Dibromo-3-chloropropane
1,2-Dibromoethane (Ethylene Dibromide)
2,3-Dibromo-1-propanol
tris(2,3-Dibromopropyl) Phosphate
1,4-Dichlorobenzene
3,3´-Dichlorobenzidine and 3,3´-Dichlorobenzidine Dihydrochloride
Dichlorodiphenyltrichloroethane (DDT)
1,2-Dichloroethane (Ethylene Dichloride)
Dichloromethane (Methylene Chloride)
1,3-Dichloropropene (Technical Grade)
Diepoxybutane
Diesel Exhaust Particulates
Diethyl Sulfate
Diethylstilbestrol
Diglycidyl Resorcinol Ether
3,3´-Dimethoxybenzidine and Dyes Metabolized to 3,3´-Dimethoxybenzidine
          3,3´-Dimethoxybenzidine
          Dyes Metabolized to 3,3´-Dimethoxybenzidine
4-Dimethylaminoazobenzene
3,3´-Dimethylbenzidine and Dyes Metabolized to 3,3´-Dimethylbenzidine
          3,3´-Dimethylbenzidine
          Dyes Metabolized to 3,3´-Dimethylbenzidine
Dimethylcarbamoyl Chloride
1,1-Dimethylhydrazine
Dimethyl Sulfate
Dimethylvinyl Chloride
1,4-Dioxane
Disperse Blue 1
Epichlorohydrin
Erionite
Estrogens, Steroidal
Ethylene Oxide
Ethylene Thiourea
di(2-Ethylhexyl) Phthalate
Ethyl Methanesulfonate
Formaldehyde (Gas)
Furan
Glass Wool (Respirable Size)
Glycidol
Hepatitis B
Hepatitis C
Heterocyclic Amines
          2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MEIQ)
          2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MEIQx)
          2-Amino-3-methylimidazo[4,5-f]quinoline (IQ)
          2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Hexachlorobenzene
Hexachloroethane
Hexamethylphosphoramide
Human Papillomaviruses: Some Genital-Mucosal Types
Hydrazine and Hydrazine Sulfate
Hydrazobenzene
Ionizing Radiation
          X-Radiation and Gamma Radiation
          Neutrons
          Radon
          Thorium Dioxide
Iron Dextran Complex
Isoprene
Kepone® (Chlordecone)
Lead and Lead Compounds
Lindane and Other Hexachlorocyclohexane Isomers
Melphalan
Methoxsalen with Ultraviolet A Therapy (PUVA)
2-Methylaziridine (Propylenimine)
4,4´-Methylenebis(2-chloroaniline)
4,4´-Methylenebis(N,N-dimethyl)benzenamine
4,4´-Methylenedianiline and its Dihydrochloride Salt
Methyleugenol
Methyl Methanesulfonate
N-Methyl-N´-nitro-N-nitrosoguanidine
Metronidazole
Michler's Ketone (4,4'-(Dimethylamino)benzophenone)
Mineral Oils (Untreated and Mildly Treated)
Mirex
Mustard Gas
Naphthalene
2-Naphthylamine
Nickel Compounds and Metallic Nickel
          Nickel Compounds
          Metallic Nickel
Nitrilotriacetic Acid
o-Nitroanisole
Nitroarenes (selected)
          1,6-Dinitropyrene
          1,8-Dinitropyrene
          6-Nitrochrysene
          1-Nitropyrene
          4-Nitropyrene
Nitrobenzene
Nitrofen (2,4-Dichlorophenyl-p-nitrophenyl Ether)
Nitrogen Mustard Hydrochloride
Nitromethane
2-Nitropropane
N-Nitrosodi-n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodiethylamine
N-Nitrosodimethylamine
N-Nitrosodi-n-propylamine
N-Nitroso-N-ethylurea
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
N-Nitroso-N-methylurea
N-Nitrosomethylvinylamine
N-Nitrosomorpholine
N-Nitrosonornicotine
N-Nitrosopiperidine
N-Nitrosopyrrolidine
N-Nitrososarcosine
Norethisterone
Ochratoxin A
4,4´-Oxydianiline
Oxymetholone
Phenacetin and Analgesic Mixtures Containing Phenacetin
          Phenacetin
          Analgesic Mixtures Containing Phenacetin
Phenazopyridine Hydrochloride
Phenolphthalein
Phenoxybenzamine Hydrochloride
Phenytoin
Polybrominated Biphenyls (PBBs)
Polychlorinated Biphenyls (PCBs)
Polycyclic Aromatic Hydrocarbons, 15 Listings
          Benz[a]anthracene
          Benzo[b]fluoranthene
          Benzo[j]fluoranthene
          Benzo[k]fluoranthene
          Benzo[a]pyrene
          Dibenz[a,h]acridine
          Dibenz[a,j]acridine
          Dibenz[a,h]anthracene
          7H-Dibenzo[c,g]carbazole
          Dibenzo[a,e]pyrene
          Dibenzo[a,h]pyrene
          Dibenzo[a,i]pyrene
          Dibenzo[a,l]pyrene
          Indeno[1,2,3-cd]pyrene
          5-Methylchrysene
Procarbazine Hydrochloride
Progesterone
1,3-Propane Sultone
ß-Propiolactone
Propylene Oxide
Propylthiouracil
Reserpine
Safrole
Selenium Sulfide
Silica, Crystalline (Respirable Size)
Soots
Streptozotocin
Strong Inorganic Acid Mists Containing Sulfuric Acid
Styrene-7,8-oxide
Sulfallate
Tamoxifen
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); "Dioxin"
Tetrachloroethylene (Perchloroethylene)
Tetrafluoroethylene
Tetranitromethane
Thioacetamide
4,4´-Thiodianiline
Thiotepa
Thiourea
Tobacco Related Exposures
          Environmental Tobacco Smoke
          Smokeless Tobacco
          Tobacco Smoking
Toluene Diisocyanate
o-Toluidine and o-Toluidine Hydrochloride
Toxaphene
Trichloroethylene
2,4,6-Trichlorophenol
1,2,3-Trichloropropane
Ultraviolet Radiation Related Exposures
          Solar Radiation
          Sunlamps or Sunbeds, Exposure to
          Broad-Spectrum Ultraviolet (UV) Radiation
          Ultraviolet A Radiation
          Ultraviolet B Radiation
          Ultraviolet C Radiation
Urethane
Vinyl Bromide
Vinyl Chloride
4-Vinyl-1-cyclohexene Diepoxide
Vinyl Fluoride
Wood Dust

IV. Tables

Table 1.Chemicals Nominated to the NTP for In-Depth Toxicological Evaluation or Carcinogenesis Testing in Fiscal Years 1988-2001

Table 2.CDC/NIOSH Response to Inquiries about Carcinogens Listed in the Eleventh Report on Carcinogens

  V. Report on Carcinogens Nomination Review Procedures

  Appendices

A. Manufacturing Processes, Occupations, and Exposure Circumstances Classified by IARC as Category 1, Carcinogenic to Humans

B. Agents, Substances, Mixtures, or Exposure Circumstances Delisted from the Report on Carcinogens

C. Agents, Substances, Mixtures, or Exposure Circumstances Reviewed but not Recommended for Listing in the Report on Carcinogens

D. List of Participants

E. Glossary

F. Acronyms and Abbreviations

G. Units of Measurement

  Indexes

A. Names and Synonyms used in RoC Substance Profiles

B. CAS Registry Numbers